Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
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چکیده
منابع مشابه
Evolution can favor antagonistic epistasis.
The accumulation of deleterious mutations plays a major role in evolution, and key to this are the interactions between their fitness effects, known as epistasis. Whether mutations tend to interact synergistically (with multiple mutations being more deleterious than would be expected from their individual fitness effects) or antagonistically is important for a variety of evolutionary questions,...
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The fitness effects of a mutation can depend, sometimes dramatically, on genetic background; this phenomenon is often referred to as "epistasis." Epistasis can have important practical consequences in the context of antimicrobial resistance (AMR). For example, genetic background plays an important role in determining the costs of resistance, and hence in whether resistance will persist in the a...
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15 صفحه اولEvolution of Antibiotic Resistance
Pietsch, F. 2015. Evolution of Antibiotic Resistance. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1150. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9380-6. The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many i...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16932-z