Highly infectious prions are not directly neurotoxic
نویسندگان
چکیده
منابع مشابه
Animal Prions Are a New Type of Infectious Agents Prions
Prions were originally defined as infectious agents of protein nature, which caused neurodegenerative diseases in animals and humans. The prion concept implies that the infectious agent is a protein in special conformation that can be transmitted to the normal molecules of the same protein through protein–protein interactions. Until the 1990s, the prion phenomenon was associated with the single...
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Transmissible spongiform encephalopathies (TSEs), otherwise known as prion disorders, are fatal diseases causing neuro degeneration in a wide range of mammalian hosts, including humans. The causative agent prions are thought to be composed of a rogue isoform of the endogenous prion protein (PrP).Prion diseases or TSEs are a group of rare but fatal neurological disorders that affect humans and a...
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The argument is made on the basis of constraints that have the same functional basis, but distinct formal properties: ONSET and *ONSET/X (§2). If phonetic factors are projected directly onto phonological constraints, then the shared functional basis of these constraints should entail that they cannot be formally distinct. Specifically, the direct-phonetics model predicts that ONSET is actually ...
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Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative diseases that affect humans and a large variety of animals. The infectious agent responsible for TSEs is the prion, an abnormally folded and aggregated protein that propagates itself by imposing its conformation onto the cellular prion protein (PrPC) of the host. PrPC is necessary for prion replication and ...
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Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuable, sensitive tool, it is currently hampered by its lack of robustness and rapidity for high-throughput purposes. Here, we made a number of improvements making it possible to amplify the maximum levels of sc...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2007406117