Highlight report: metabolism and toxicity by fumonisins
نویسندگان
چکیده
منابع مشابه
Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
Sphingolipids have important roles in membrane and lipoprotein structure and in cell regulation as second messengers for growth factors, differentiation factors, cytokines, and a growing list of agonists. Bioactive sphingolipids are formed both by the turnover of complex sphingolipids and as intermediates of sphingolipid biosynthesis. Usually, the amounts are highly regulated; however, by inhib...
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متن کاملTHE RELATIONSHIP BETWEEN ALUMINIUM TOXICITY AND IRON METABOLISM IN RATS
The relationship between aluminium toxicity and iron metabolism was studied. Male rats were exposed to aluminium by daily intraperitoneal injection of 40pmolelkg body weight. After 45 days, aluminium intoxified rats had a significant loweredserum ferritin (55%), iron (42%), TIBC (25%) and hemoglobin(31%). At thesame time the serum ceruloplasmin level was elevated by 60%. This result shows t...
متن کاملEvidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins.
Fumonisins are inhibitors of the biosynthesis of sphingosine and more complex sphingolipids. In eucaryotic cells, fumonisin inhibition of sphingolipid biosynthesis is a result of inhibition of the enzyme ceramide synthase. Large increase in free sphinganine concentration in plant and animal cells are observed within a few hours after exposure to fumonisins and/or Alternaria toxins (AAL-toxins)....
متن کاملFactors influencing metabolism and toxicity of metals: a consensus report.
A series of meetings concerning metal toxicology have been organized by the Scientific Committee on the Toxicology of Metals under the Permanent Commission and International Association on Occupational Health. Accumulation of toxic metals with special reference to their absorption, excretion, and biological half-times was discussed in Slanchev Bryag, Bulgaria, 1971, and in Buenos Aires, 1972. D...
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ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2015
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-015-1645-z