High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia
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چکیده
منابع مشابه
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expression in hematopoietic progenitors and give rise to an aggressive subtype of acute myeloid leukemia (AML). Insights into MLL fusion-mediated leukemogenesis have not yet translated into better therapies because MLL is difficult to target directly, and the identity of the genes ...
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Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Consortium for Translational Cancer Research, Heidelberg, Germany; Department of Internal Medicine III, Ulm University, Ulm, Germany; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Haematology, Cambridge Institute of Med...
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ژورنال
عنوان ژورنال: Translational Oncology
سال: 2021
ISSN: 1936-5233
DOI: 10.1016/j.tranon.2021.101048