High-Resolution fMRI Reveals Laminar Differences in Neurovascular Coupling between Positive and Negative BOLD Responses
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چکیده
منابع مشابه
High-Resolution fMRI Reveals Laminar Differences in Neurovascular Coupling between Positive and Negative BOLD Responses
The six cortical layers have distinct anatomical and physiological properties, like different energy use and different feedforward and feedback connectivity. It is not known if and how layer-specific neural processes are reflected in the fMRI signal. To address this question we used high-resolution fMRI to measure BOLD, CBV, and CBF responses to stimuli that elicit positive and negative BOLD si...
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Introduction While the dynamics and mechanism of the positive BOLD response have been well studied, much less is known about the mechanism of the negative BOLD response. Although the negative BOLD response is related to decreases in neural activity [1] and in CBF [2], the temporal dynamics differ from that of the positive BOLD signal [1]. Here, we studied the properties of the negative BOLD res...
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Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOL...
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BACKGROUND The blood oxygenation-level dependent (BOLD) functional magnetic resonance imaging (fMRI) modality has been numerically simulated by calculating single voxel signals. However, the observation on single voxel signals cannot provide information regarding the spatial distribution of the signals. Specifically, a single BOLD voxel signal simulation cannot answer the fundamental question: ...
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Introduction: Recently, a novel BOLD fMRI method based on a modified half Fourier single shot TSE technique, namely mHASTE, has been explored and discussed [1,2]. In comparison with the widespread EPI sequences (e.g. GEand SE-EPI), mHASTE offers artifactand distortion-free functional images, higher signal-to-noise ratio (SNR) and potentially better function specificity, while achieving comparab...
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ژورنال
عنوان ژورنال: Neuron
سال: 2012
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2012.09.019