High-Quality Postnatal Care Is Essential

Primary care oncology: essential if high quality cancer care is to be achieved for all.

Cardiomyocyte Ogt is essential for postnatal viability.

The singly coded gene O-linked-β-N-acetylglucosamine (O-GlcNAc) transferase (Ogt) resides on the X chromosome and is necessary for embryonic stem cell viability during embryogenesis. In mature cells, this enzyme catalyzes the posttranslational modification known as O-GlcNAc to various cellular proteins. Several groups, including our own, have shown that acute increases in protein O-GlcNAcylatio...

Patient-centered comparative effectiveness research: essential for high-quality care.

Is primary care essential?

Notch ligand Delta-like 1 is essential for postnatal arteriogenesis.

Growth of functional arteries is essential for the restoration of blood flow to ischemic organs. Notch signaling regulates arterial differentiation upstream of ephrin-B2 during embryonic development, but its role during postnatal arteriogenesis is unknown. Here, we identify the Notch ligand Delta-like 1 (Dll1) as an essential regulator of postnatal arteriogenesis. Dll1 expression was specifical...