High prevalence of qnrA and qnrB genes among fluoroquinolone-resistant Escherichia coli isolates from a tertiary hospital in Southern Nigeria

Abstract Background This study was aimed to determine the prevalence of qnr genes among fluoroquinolone-resistant Escherichia coli (FREC) isolates from Nigeria. Antimicrobial susceptibility testing performed by disc diffusion technique. Polymerase chain reaction used identify ( E. ) and for detection genes. Results A total 206 non-duplicate were isolated 300 clinical specimens analyzed. In all, 30 (14.6%) these FREC; resistance fluoroquinolones FREC showed 80% (24), 86.7% (26), 100% (30), 93.3% (28) (26) resistant pefloxacin, ciprofloxacin, sparfloxacin, levofloxacin, nalidixic acid, ofloxacin moxifloxacin, respectively. The distribution various sample sources analyzed that 14%, 10%, 13.3%, 16.7% 20% came urine, stool, high vaginal swab, endo cervical swab wound specimens, More female samples 73.3% (22) compared male 26.7% (8) more prevalent age group 26–35 years (40%). Twenty eight out (93.3%) possessed at least one fluoroquinolone gene in form qnrA 10 (33.3%) qnrB 18 (60%), respectively; qnrS not detected 13.5% both Phylogenetic analysis genetically diverse. Conclusions These findings suggest a possible is interest better management patients control antimicrobial