High-mobility group box 1 protein, angiotensins, ACE2, and target organ damage
نویسندگان
چکیده
منابع مشابه
Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
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High mobility group box 1 (HMGB1), a non-histone DNA-binding protein, regulates nucleosome function and transcription in the nuclei of all metazoans and plants. However, extracellular HMGB1, which is actively or passively released under different conditions, can act as a key inflammatory mediator through MyD88/mitogen-activated protein kinase signaling by binding to its receptors including the ...
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Since its identification a third of a century ago, the high-mobility group box-1 (HMGB1) protein has been linked to varied diverse cellular processes, including release from necrotic cells and secretion by activated macrophages engulfing apoptotic cells. Initially described as solely chromatin-associated, HMGB1 was additionally discovered in the cytoplasm of several types of cultured mammalian ...
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ژورنال
عنوان ژورنال: Journal of Molecular Medicine
سال: 2015
ISSN: 0946-2716,1432-1440
DOI: 10.1007/s00109-015-1372-1