High Levels of Circulating IL-6 and IL-8 Signature can Predict COVID-19 Severity

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may trigger a cytokine storm, which is characterized by uncontrolled overproduction of proinflammatory cytokines. Objectives: We aimed to investigate the association between circulating levels inflammatory cytokines and severity disease 2019 (COVID-19). Methods: This cross-sectional study included 46 severe 32 mildly symptomatic COVID-19 patients. The serum chemokines were determined using Bio-Plex ProTM Human Cytokine Screening Panel. Results: Out total 78 patients with confirmed COVID-19, 54 (69.2%) males, 24 (30.8%) females. mean age was 43.1 ± 13.3 58.2 15 in mild patients, respectively. significant laboratory abnormalities, such as increased WBC (P = 0.002) neutrophil counts 0.001), higher ALT 0.03), AST 0.002), LDH < urea 0.013), ferritin D-dimer 0.042), CRP decreased lymphocyte 0.001) platelet 0.045) counts. IL-6, IL-8, IL-13, TNF-α, IFN-γ, MIP-1β, MCP-1 group compared group. However, differences observed only for IL-6 IL-8 levels. Conclusions: Serum can be used potential prognostic biomarkers