High-Level Production of Recombinant Human Parathyroid Hormone 1-34
نویسندگان
چکیده
منابع مشابه
a novel approach for high level expression of soluble recombinant human parathyroid hormone (rhpth 1-34) in escherichia coli
background: parathyroid hormone (pth) secreted by parathyroid glands regulates the metabolism of calcium and phosphorus in bone and kidney. thereby, it can stimulate bone formation, and is a promising agent in the treatment of osteoporosis. mature form of pth consists of 84 amino acids; however, the first 34 residues of pth cover the majority of hormonal action. methods: in this study, the fusi...
متن کاملA Novel Approach for High Level Expression of Soluble Recombinant Human Parathyroid Hormone (rhPTH 1-34) in Escherichia coli
BACKGROUND Parathyroid hormone (PTH) secreted by parathyroid glands regulates the metabolism of calcium and phosphorus in bone and kidney. Thereby, it can stimulate bone formation, and is a promising agent in the treatment of osteoporosis. Mature form of PTH consists of 84 amino acids; however, the first 34 residues of PTH cover the majority of hormonal action. METHODS In this study, the fusi...
متن کاملRecombinant human parathyroid hormone 1-84 (Natpara)
Description/Mechanism of Action Recombinant human parathyroid hormone (rhPTH 1-84) is identical to endogenous parathyroid hormone (PTH) and binds PTH-1 receptors in the bone, kidney, and has an indirect effect on calcium reabsorption in the intestine. It increases serum calcium by increasing renal tubular calcium reabsorption, intestinal calcium absorption, and bone turnover. Indication under R...
متن کاملAddressing the tertiary structure of human parathyroid hormone-(1-34).
Parathyroid hormone (PTH) regulates mineral metabolism and bone turnover by activating specific receptors located on osteoblastic and renal tubular cells and is fully functional as the N-terminal 1-34 fragment, PTH-(1-34). Previously, a "U-shaped" conformation with N- and C-terminal helices brought in close proximity by a turn has been postulated. The general acceptance of this hypothesis, desp...
متن کاملTeriparatide (recombinant human parathyroid hormone 1-34) in postmenopausal women with osteoporosis: systematic review.
CONTEXT AND OBJECTIVE Osteoporosis is defined as a disease characterized by low bone mass and deterioration of the bone tissue microarchitecture. Teriparatide stimulates the formation and action of osteoblasts, which are responsible for bone formation, thus promoting bone tissue increase. The aim was to assess the effectiveness and safety of teriparatide for treating postmenopausal osteoporosis...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 1998
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.64.2.526-529.1998