High kinetic energy-ion mobility spectrometry-mass spectrometry investigations of several volatiles and their fully deuterated analogues

Abstract The first High Kinetic Energy-Ion Mobility Spectrometry-Mass Spectrometry (HiKE-IMS-MS) studies involving six volatiles (acetone, acetonitrile, methanol, ethanol, 2-propanol, and 1-butanol) their fully deuterated analogues are reported. goal is to further our understanding of the ion–molecule chemistry occurring in HiKE-IMS. This needed for its full analytical potential be reached. Product ions identified as a function reduced electric field (30–115 Td) influence sample air humidity reaction region on deuterium/hydrogen (D/H) exchange reactions discussed. Reagent include H 3 O + (H 2 O) m ( n = 0, 1, or 3), NO 0 1) +· . Reactions with lead protonated monomers (through either proton transfer ligand switching). involve association acetone hydride anion abstraction from 1-butanol, hydroxide 2-propanol 1-butanol. With exception predominantly reacts via dissociative charge transfer. A number sequential secondary ion-volatile processes occur leading formation dimer trimer-containing ion species, whose intensities depend volatile’s concentration region. Deuterium/hydrogen does not product acetone-d 6 acetonitrile-d , owing inert methyl functional groups. For alcohols, rapid D/H-exchange at hydroxy group observed, amount which increased increasing and/or lowering field. Graphical abstract