High INtensity Interval Training in pATiEnts with Intermittent Claudication (INITIATE): A Feasibility Proof-of-concept Study

Provision, uptake, adherence, and completion rates for supervised exercise programs (SEPs) intermittent claudication (IC) are low. For patients, 12-week SEPs too time-intensive. A shorter, more time-efficient, 6-week, high-intensity interval training (HIIT) program may be an effective alternative that is acceptable to patients easier deliver. The aim of this study was determine the feasibility HIIT with IC. This a single group, two-center, proof-of-concept study. performed in secondary care included IC who were referred usual-care SEPs. three times per week 6 weeks involved 1:1 work rest ratio. Outcomes feasibility, tolerability, potential safety, efficacy. Some 280 screened, 165 (59%) eligible 40 (25%) recruited HIIT. majority (n = 31; 78%) completed Of nine excluded or withdrew, (7.5%) unable tolerate procedures. Patients attended 99% sessions, 85% sessions full, 84% intervals at required intensity. There no related serious adverse events. mean improvements maximal walking distance physical component summary 94 m (95% confidence interval, 66.6-120.8 m), 2.2 0.3-4.1) respectively. Uptake comparable SEPs, but higher. Most improvement summary. appears feasible, tolerable, potentially safe beneficial It provide deliverable, form SEP. Further research comparing warranted.