High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain

Live, Optical Experimental Neuroimaging Reveals Variations of the Cerebral Blood Flow Response to Ischemic Spreading Depolarization

Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain.

Diffuse optical correlation methods were adapted for three-dimensional (3D) tomography of cerebral blood flow (CBF) in small animal models. The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization. The tomographic approach was demonstrated with simulated data and during in-vivo cortical spreading depress...

Quantitative evaluation of Blood Brain Barrier permeability in transient focal cerebral ischemia in the rat

Introduction: Development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. Blood brain barrier (BBB) opening is an important part of edema named as vasogenic brain edema. In this study, quantitative alterations of BBB permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. Methods: Two groups of male rats (ischemic and sh...

Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response

The significance of prostanoid signaling in neurovascular coupling during somatosensory stimulation is increasingly more appreciated, yet its involvement in mediating the cerebral blood flow (CBF) response to spreading depolarization (SD) has remained inconclusive. Selective cyclooxygenase (COX) enzyme inhibitors (NS-398, SC-560) or an antagonist (L161,982) of the EP4 type prostaglandin E2 rece...

Calcium channel blockers correct acidosis in ischemic rat brain without altering cerebral blood flow.

We compared the effects of intravenous infusions of 40 micrograms/kg/min verapamil (n = 5), 0.5 microgram/kg/min nimodipine (n = 5), and 5 ng/kg/min prostacyclin (n = 6) and no treatment (n = 6) on local cerebral pH and local cerebral blood flow in middle cerebral artery-occluded rats 90 minutes after the ischemic insult. Local cerebral pH and local cerebral blood flow were determined simultane...