High Guanine and Cytosine Content Increases mRNA Levels in Mammalian Cells

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High Guanine and Cytosine Content Increases mRNA Levels in Mammalian Cells

Mammalian genes are highly heterogeneous with respect to their nucleotide composition, but the functional consequences of this heterogeneity are not clear. In the previous studies, weak positive or negative correlations have been found between the silent-site guanine and cytosine (GC) content and expression of mammalian genes. However, previous studies disregarded differences in the genomic con...

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ژورنال

عنوان ژورنال: PLoS Biology

سال: 2006

ISSN: 1545-7885

DOI: 10.1371/journal.pbio.0040180