High-grade mutant OmpF induces decreased bacterial survival rate.

High-grade mutant OmpF induces decreased bacterial survival rate.

OmpF plays very important roles in the influx of antibiotics and bacterial survival in the presence of antibiotics. However, high-grade mutant OmpF and its function in decreasing bacterial survival rate have not been reported to date. In the present study, we cloned a high-grade mutant OmpF (mOmpF) and sequence analysis suggested that over 45 percent of the DNA sequence was significantly mutate...

Improvement in High-Grade Osteosarcoma Survival

The aim of this study was to compare survival before and after 2004 and define the prognostic factors for high-grade osteosarcomas beyond those of typical young patients with localized extremity disease. Few studies have reported the long-term treatment outcomes of high-grade osteosarcoma in Taiwan. A total of 202 patients with primary high-grade osteosarcoma who received primary chemotherapy a...

High Grade Gliomas Hg-01. Etoposide Improves Survival in High Grade Glioma: a Meta-analysis

BACKGROUND: Despite standard therapy, high grade gliomas (HGGs) have a very poor prognosis. There are numerous phase I and phase II trials investigating novel agents and multimodal approaches that seek to improve upon survival in these patients. The purpose of this study was to evaluate the therapeutic efficacy of topoisomerase inhibitors in the treatment of HGGs. METHODS: We compared the effic...

MiR-328 Expression Is Decreased in High-Grade Gliomas and Is Associated with Worse Survival in Primary Glioblastoma

MicroRNAs, a group of small endogenous, noncoding RNAs, are aberrantly expressed in many human cancers and can act as oncogene or anti-oncogene. Recent evidence suggests that some miRNAs have prognostic value for tumors. MiR-328 is known as a tumor suppressor; however, its relationship with the clinicopathological features of glioblastoma (GBM) and its prognostic value has yet not been investig...

Rate of osmotic downshock determines bacterial survival probability