High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma
نویسندگان
چکیده
منابع مشابه
Triple-layer dissection of the lung adenocarcinoma transcriptome – regulation at the gene, transcript, and exon levels
Lung adenocarcinoma is one of the most deadly human diseases. However, the molecular mechanisms underlying this disease, particularly RNA splicing, have remained underexplored. Here, we report a triple-level (gene-, transcript-, and exon-level) analysis of lung adenocarcinoma transcriptomes from 77 paired tumor and normal tissues, as well as an analysis pipeline to overcome genetic variability ...
متن کاملMutation Profile to Predict Tumor Stage in Lung Adenocarcinoma
Lung adenocarcinoma is among the most common and deadliest cancers in the United States, accounting for an estimated 120,000 new cases every year, and responsible for nearly 10% of cancer deaths [7]. Because of its prevalence and high mortality rate, it is important to understand the histological progression of lung cancers. In this work, I classified tumor stage based on mutations in genes wit...
متن کاملFunctional divergence and convergence between the transcript network and gene network in lung adenocarcinoma.
INTRODUCTION Alternative RNA splicing is a critical regulatory mechanism during tumorigenesis. However, previous oncological studies mainly focused on the splicing of individual genes. Whether and how transcript isoforms are coordinated to affect cellular functions remain underexplored. Also of great interest is how the splicing regulome cooperates with the transcription regulome to facilitate ...
متن کاملPossible pathways used to predict different stages of lung adenocarcinoma
We aimed to find some specific pathways that can be used to predict the stage of lung adenocarcinoma.RNA-Seq expression profile data and clinical data of lung adenocarcinoma (stage I [37], stage II 161], stage III [75], and stage IV [45]) were obtained from the TCGA dataset. The differentially expressed genes were merged, correlation coefficient matrix between genes was constructed with correla...
متن کاملIMP3 can predict aggressive behaviour of lung adenocarcinoma
BACKGROUND Lung cancer most often presents as an inoperable tumour and the diagnosis is usually performed on a small biopsy/cytology specimen. In the group of non small cell lung cancer - not otherwise specified, adenocarcinoma phenotype can be determined immunohistochemically using TTF-1 and Napsin A. Expression of oncofetal protein IMP3 in human cancer is associated with poor differentiation ...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2019
ISSN: 0022-2275
DOI: 10.1194/jlr.m093955