High-Dose Vitamin D Supplementation in People With Prediabetes and Hypovitaminosis D

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High-Dose Vitamin D Supplementation in People With Prediabetes and Hypovitaminosis D

OBJECTIVE Low vitamin D levels predict the development of diabetes. This double-blind, randomized, control study in subjects with prediabetes and hypovitaminosis D evaluated whether high doses of vitamin D for 1 year affected insulin secretion, insulin sensitivity, and the development of diabetes. RESEARCH DESIGN AND METHODS A total of 1,551 subjects ≥40 years of age not known to have diabete...

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Response to Comment on: Davidson et al. High-Dose Vitamin D Supplementation in People With Prediabetes and Hypovitaminosis D. Diabetes Care 2013;36:260–266

This letter is in response to Pilz et al. (1) who are concerned about the possible long-term effects of high levels of vitamin D on mortality. In a sense, our study was a “proof of concept” one. As noted in our article (2) and in its Supplementary Table 3, there have been a number of studies evaluating the effect of vitamin D supplementation on diabetes, insulin secretion, and insulin sensitivi...

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Comment on: Davidson et al. High-Dose Vitamin D Supplementation in People With Prediabetes and Hypovitaminosis D. Diabetes Care 2013;36:260–266

In their recently published randomized, controlled trial (RCT), Davidson et al. (1) found no significant effect of highdose vitamin D supplementation on insulin secretion, insulin sensitivity, and incident diabetes. Their RCT is of particular importance because the researchers included subjects with diabetes and vitamin D insufficiency, i.e., a cohort that according to previous observational st...

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Treatment of vitamin D deficiency with high-dose vitamin D supplementation and its effect on hematological indices in pregnancy: A secondary analysis of a randomized clinical trial

Introduction: There are few studies regarding the treatment of vitamin D deficiency with a high dose of vitamin D and the comparison of serum vitamin D levels and hematological indices (Hemoglobin, Hematocrit, Platelet and Ferritin) in the first and second trimesters of pregnancy. The aim of this study was to evaluate the effect of vitamin D supplementation on these hematological indices in pre...

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Effect of Vitamin D Therapy on Hashimoto's Thyroiditis in Children with Hypovitaminosis D

Background Hashimoto's thyroiditis (HT) is a common cause of thyroid diseases in children and the role of vitamin D (VD) is controversial. Therefore, the aim of this study was to investigate the influence of VD therapy on HT in children with hypovitaminosis D.<br...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2012

ISSN: 0149-5992,1935-5548

DOI: 10.2337/dc12-1204