High dose psilocybin is associated with positive subjective effects in healthy volunteers
نویسندگان
چکیده
منابع مشابه
Prediction of Psilocybin Response in Healthy Volunteers
Responses to hallucinogenic drugs, such as psilocybin, are believed to be critically dependent on the user's personality, current mood state, drug pre-experiences, expectancies, and social and environmental variables. However, little is known about the order of importance of these variables and their effect sizes in comparison to drug dose. Hence, this study investigated the effects of 24 predi...
متن کاملPsilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers.
BACKGROUND The amygdala is a key structure in serotonergic emotion-processing circuits. In healthy volunteers, acute administration of the serotonin 1A/2A/2C receptor agonist psilocybin reduces neural responses to negative stimuli and induces mood changes toward positive states. However, it is little-known whether psilocybin reduces amygdala reactivity to negative stimuli and whether any change...
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EUROPSYCHOPHARMACOLOGY 1999 – VOL . 20 , NO . 6 © 1999 American College of Neuropsychopharmacology Published by Elsevier Science Inc. 0893-133X/99/$–see front matter 655 Avenue of the Americas, New York, NY 10010 PII S0893-133X(98)00089-X Neurometabolic Effects of Psilocybin, 3,4-Methylenedioxyethylamphetamine (MDE) and d-Methamphetamine in Healthy Volunteers A Double-Blind, Placebo-Controlled ...
متن کاملThe effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers
Perturbing a system and observing the consequences is a classic scientific strategy for understanding a phenomenon. Psychedelic drugs perturb consciousness in a marked and novel way and thus are powerful tools for studying its mechanisms. In the present analysis, we measured changes in resting-state functional connectivity (RSFC) between a standard template of different independent components a...
متن کاملEffects of high-dose inhaled fluticasone propionate via spacer on cell-mediated immunity in healthy volunteers.
BACKGROUND Systemic corticosteroids are known to alter cell-mediated immunity (CMI). However, the effects of inhaled steroids on CMI are unclear. We therefore sought to assess CMI following high-dose inhaled steroids in healthy subjects. METHODS Ten healthy nonasthmatic subjects self-administered fluticasone propionate (FP), 440 microg bid, with a spacer device. CMI was assessed by delayed hy...
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ژورنال
عنوان ژورنال: Journal of Psychopharmacology
سال: 2018
ISSN: 0269-8811,1461-7285
DOI: 10.1177/0269881118780713