High-dose influenza vaccine favors acute plasmablast responses rather than long-term cellular responses
نویسندگان
چکیده
منابع مشابه
An HIV-1 Mini Vaccine Induced Long-lived Cellular and Humoral Immune Responses
Memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. The main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. Mice were immunized with human immunodeficiency virus-1 P24-Nef fusion peptide and then cellular and humoral immune responses were evaluated. In order to determin...
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Some antigens induce Ab responses without T lymphocyte help. Among these, many polysaccharide-based antigens cause marginal zone B cells to proliferate and differentiate into plasma cells. B1 cells also respond to some of these antigens. In this article, we report that antigen-specific B1b cells, in response to the T-independent antigen (4-hydroxy-3-nitrophenyl)-acetyl (NP)-Ficoll, develop into...
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BACKGROUND Despite vaccination, residents of long-term-care facilities (LTCFs) remain at high risk of influenza-related morbidity and mortality. More-effective vaccine options for this population are needed. METHODS We conducted a single-blinded, randomized, controlled trial comparing high-dose (HD) to standard-dose (SD) inactivated influenza vaccine (IIV) in 205 frail, elderly residents of L...
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memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. the main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. mice were immunized with human immunodeficiency virus-1 p24-nef fusion peptide and then cellular and humoral immune responses were evaluated. in order to determin...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2016
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2016.07.018