High-dose cytarabine in upfront therapy for adult patients with acute lymphoblastic leukaemia
نویسندگان
چکیده
منابع مشابه
Rescue therapy combining intermediate-dose cytarabine with amsacrine and etoposide in relapsed adult acute lymphoblastic leukemia.
In all, 625 patients with acute lymphoblastic leukemia (ALL) entered the Leucémie Aiguë Lymphoblastique de l'Adulte-94 trial from June 1994 to June 1999, and received a 4-week induction therapy followed either by chemotherapy alone or stem cell transplantation (SCT). In a clinical phase II study, 40 patients with standard- or high-risk ALL - except Philadelphia chromosome-positive ALL -, relaps...
متن کاملAmsacrine with high-dose cytarabine is highly effective therapy for refractory and relapsed acute lymphoblastic leukemia in adults.
Thirty-six patients with relapsed acute lymphoblastic leukemia (ALL) and four with primary refractory ALL were treated with a regimen that included amsacrine, 200 mg/m2, intravenously daily for three days with cytarabine, 3 gm/m2, by infusion over three hours daily for five days. There were 27 remissions in the 36 relapsed patients and two in the four patients with primary refractory disease. S...
متن کاملHigh hyperdiploid acute lymphoblastic leukaemia
Prognosis for children is good with long term survival of 70%-80%; adults do less well although event free survival of 59% at 3 years has been reported; the good prognosis is thought to be related to leukaemic cell sensitivity to a number of anti-leukaemic drugs and the propensity of cells to respond by apoptosis; it is unclear why a proportion of patients fail to achieve long term remission bu...
متن کاملThe feasibility of opal/high dose Ara-C treatment of adult acute lymphoblastic leukaemia.
Studies conducted at St. Bartholomew's Hospital between 1972 and 1982 into the treatment of acute lymphoblastic leukaemia (ALL) in adults showed a complete remission (CR) rate of 65% (73/112) using a combination of vincristine, prednisolone, adriamycin, and L-asparaginase, with. CR frequency being highest in young patIents and lowest in those with L3 morphology. The duration of remission correl...
متن کاملImmunophenotypic Subtyping of Leukemic Cells from Iranian Patients with Acute Lymphoblastic Leukaemia: Association to Disease Outcome
Background: Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification, stratification and prognosis of leukaemia. Objective: To investigate the immunophenotypic subtype profiles of Iranian patients with acute lymphoblastic leukemia (ALL) and its association to disease outcome. Methods: In this study, a total of 60 Iranian patients with ...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2002
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2002.03685.x