High definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndrome
نویسندگان
چکیده
منابع مشابه
High definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndrome.
Highly reliable biomarkers for the diagnosis of neurological diseases are not widely available. Here we evaluated a luciferase immunoprecipitation technology (LIPS) for the diagnosis of a CNS autoimmune disorder, stiff-person syndrome (SPS). Analysis by LIPS of 40 sera samples from SPS and control subjects for anti-GAD65 antibodies revealed dramatic titer differences allowing diagnosis of SPS w...
متن کاملNeuronal surface and glutamic acid decarboxylase autoantibodies in Nonparaneoplastic stiff person syndrome.
IMPORTANCE High titers of autoantibodies to glutamic acid decarboxylase (GAD) are well documented in association with stiff person syndrome (SPS). Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA), and impaired function of GABAergic neurons has been implicated in the pathogenesis of SPS. Autoantibodies to GAD might be the causative agent or a...
متن کاملAnalysis of GAD65 autoantibodies in Stiff-Person syndrome patients.
Autoantibodies to the 65-kDa isoform of glutamate decarboxylase GAD65 (GAD65Ab) are strong candidates for a pathological role in Stiff-Person syndrome (SPS). We have analyzed the binding specificity of the GAD65Ab in serum and cerebrospinal fluid (CSF) of 12 patients with SPS by competitive displacement studies with GAD65-specific rFab-derived from a number of human and mouse mAbs specific for ...
متن کاملLockjaw in stiff-person syndrome with autoantibodies against glycine receptors
A 37-year-old man was admitted to our hospital in 1998 with severe contraction of both masseter muscles, which made him unable to open his mouth. He could only drink using a straw fitting through a tooth gap. Spasms of the facial and masseter muscles had started in 1993 and transiently improved after treatment with benzodiazepines. The patient’s history included treatment of back and joint pain...
متن کاملStiff eyes in stiff-person syndrome.
since 1951, it is now a weekly with 48 issues per year.
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2008
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.11.077