High Clinical and Genetic Similarity Between Chronic Pancreatitis Associated With Light-to-Moderate Alcohol Consumption and Classical Alcoholic Chronic Pancreatitis

Background and Aims Heavy alcohol consumption genetic factors represent the 2 major etiologies of chronic pancreatitis (CP). However, little is so far known about clinical features basis light-to-moderate consumption-related CP (LMA-CP). Methods A cross-sectional analysis was performed on 1061 Chinese patients between 2010 2015. classified as classical alcoholic (ACP; n = 206), LMA-CP (n 154), idiopathic (ICP; 701). Clinical characteristics (PRSS1, SPINK1, CTRC, CFTR variant status) were compared different groups. Odds ratios (ORs) with 95% confidence intervals calculated to ascertain combinatorial effect gene mutation. Results Compared ICP, characterized by higher rates developing pancreatic stones, pseudocyst, diabetes, steatorrhea, which similar those associated ACP. The prevalence CP-related variants in 38.3%, ACP (39.8%), although significantly lower than ICP (56.2%). Alcohol enhanced risk a poor outcome, whereas amplified alcohol's effects. high stones (patients without variants, OR 2.01 2.54; 2.17 1.07), pseudocyst 1.03 1.43; 1.67 2.14), diabetes mellitus 0.86 1.31; 2.05 1.55), steatorrhea 1.56 2.10; 2.11 1.60). Conclusions Evidence presented show that clinically genetically but from ICP. Our findings provide support growing view there no safe level consumption.