High Cardiovascular Risk in Older Men with Poor Bone Microarchitecture—The Prospective <scp>STRAMBO</scp> Study

Data on the association between bone microarchitecture and cardiovascular disease (CVD) in men are scarce. We studied link of areal mineral density (aBMD) with risk major adverse coronary event (MACE) a cohort aged 60 to 87 years followed prospectively for 8 years. At baseline, aBMD was measured using Hologic Discovery-A device. Bone assessed at distal radius tibia by high-resolution peripheral quantitative computed tomography (XtremeCT Scanco device). During study, 53 had incident MACE. The analyses were adjusted confounders related CVD. In 813 (53 MACEs), higher lumbar spine, hip, whole body, associated lower MACE (hazard ratio [HR] = 0.44–0.71/SD, p < .025 .001). 745 having valid scan (47 cortical (Ct.BMD) thickness (Ct.Thd) This lowest quintile measures versus four upper quintiles combined (Ct.BMD: HR 2.12, 95% confidence interval [CI] 1.08–4.17, .025). Findings similar 779 (48 MACEs). both sites, estimated stiffness failure load strength jointly (distal stiffness: 2.46, CI 1.27–4.74, .01). Similar results obtained 638 without prior fragility fracture 689 ischemic heart baseline. Thus, older years, aBMD, preserved status, after adjustment relevant confounders. © 2021 American Society Mineral Research (ASBMR).