High burden of private mutations due to explosive human population growth and purifying selection
نویسندگان
چکیده
منابع مشابه
Distortions in genealogies due to purifying selection.
Purifying selection can substantially alter patterns of molecular evolution. Its main effect is to reduce overall levels of genetic variation, leading to a reduced effective population size. However, it also distorts genealogies relative to neutral expectations. A structured coalescent method has been used to describe this effect, and forms the basis for numerical methods and simulations. In th...
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The advent of next-generation sequencing technology has allowed the collection of vast amounts of genetic variation data. A recurring discovery from studying larger and larger samples of individuals had been the extreme, previously unexpected, excess of very rare genetic variants, which has been shown to be mostly due to the recent explosive growth of human populations. Here, we review recent l...
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Purifying selection at many linked sites alters patterns of molecular evolution, reducing overall diversity and distorting the shapes of genealogies. Recombination attenuates these effects; however, purifying selection can significantly distort genealogies even for substantial recombination rates. Here, we show that when selection and/or recombination are sufficiently strong, the genealogy at a...
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Human population growth as proximate cause of wetland dynamics
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2014
ISSN: 1471-2164
DOI: 10.1186/1471-2164-15-s4-s3