High apolipoprotein E4 allele frequency in FXTAS patients
نویسندگان
چکیده
منابع مشابه
Apolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease.
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Background and Purpose—The clinical significance of the apoE e4 allele in white matter changes in patients with dementia has been a subject of debate. We studied the association between the apoE e4 allele and white matter hyperintensities (WMHs) before and after control for (1) potential vascular risk factors and (2) the presence of lacunar infarcts in patients with dementia. Methods—The subjec...
متن کاملAmyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people.
BACKGROUND The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood. OBJECTIVE To test the hypothesis that amyloid load can account for (mediate) the association of the APOE e4 allele with level of cognition assessed proximate to death. METHODS There were 44 subjects with clinically diagnosed Alzheimer's di...
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ژورنال
عنوان ژورنال: Genetics in Medicine
سال: 2013
ISSN: 1098-3600,1530-0366
DOI: 10.1038/gim.2013.12