HGG-11. APPLICATION OF SHUNT IN PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA COMPLICATED WITH HYDROCEPHALUS: A 10-YEAR EXPERIENCE FROM A SINGLE CENTER

Abstract OBJECTIVE Currently, there is no unified treatment protocol for pediatric diffuse intrinsic pontine glioma with hydrocephalus. The present study aims to explore the clinical characteristics and best intervention modality METHODS detailed data of children admitted Department Pediatrics Guangdong Sanjiu Brain Hospital from January 2010 December 2021 were retrospectively analyzed. effect radiotherapy shunt on prognosis complicated hydrocephalus was evaluated. RESULTS 165 DIPG aged ≤18 years included in analysis, whom 9 (5.5%) had mild ventricular dilatation, 48 (35%) hydrocephalus, 11 (22.9%) underwent cerebrospinal fluid shunting, 10 (90.9%) ventriculoperitoneal 1 (9.1%) endoscopic third ventriculostomy. After radiotherapy, 53 cases could be evaluated, which 37 patients (69.8%) significantly relieved, 16 (30.2%) not. 99 tumor progression after treatment, including 41 (41.4%) 5 (12.2%) shunt. A total 138 survival revealed that abnormality (p=0.944). at initial diagnosis did not affect prognosis, p=0.405. median remission group post-radiotherapy 12 months, 8 months non-remission group, p=0.042. 20 untreated (p=0.005). CONCLUSIONS Asymptomatic enlargement gliomas does require surgical intervention. Hydrocephalus a favorable prognostic indicator. Cerebrospinal improve when progresses post-radiotherapy.