Heterozygous loss of epilepsy gene KCNQ2 alters social, repetitive and exploratory behaviors
نویسندگان
چکیده
منابع مشابه
Handling newborn monkeys alters later exploratory, cognitive, and social behaviors
Touch is one of the first senses to develop and one of the earliest modalities for infant-caregiver communication. While studies have explored the benefits of infant touch in terms of physical health and growth, the effects of social touch on infant behavior are relatively unexplored. Here, we investigated the influence of neonatal handling on a variety of domains, including memory, novelty see...
متن کاملNovel mutations in the KCNQ2 gene link epilepsy to a dysfunction of the KCNQ2-calmodulin interaction.
M utations in the voltage gated potassium channels KCNQ2 (OMIM 602235) and KCNQ3 (OMIM 602232) are associated with an autosomal dominant idiopathic epilepsy syndrome of newborns, benign familial neonatal seizures (BFNS) (OMIM 121200). BFNS is characterised by unprovoked partial seizures typically beginning when the infant is around three days old. BFNS associated genes were mapped to human chro...
متن کاملONLINE MUTATION REPORT Novel mutations in the KCNQ2 gene link epilepsy to a dysfunction of the KCNQ2-calmodulin interaction
M utations in the voltage gated potassium channels KCNQ2 (OMIM 602235) and KCNQ3 (OMIM 602232) are associated with an autosomal dominant idiopathic epilepsy syndrome of newborns, benign familial neonatal seizures (BFNS) (OMIM 121200). BFNS is characterised by unprovoked partial seizures typically beginning when the infant is around three days old. BFNS associated genes were mapped to human chro...
متن کاملCalmodulin regulates KCNQ2 function in epilepsy.
Epilepsy is linked to mutations in KCNQ channels. KCNQ channels including KCNQ2 and KCNQ3 are enriched in neurons, regulating action potential generation and modulation. Here, we showed that properties of KCNQ2 channel in rat hippocampal cultured neurons are regulated by ubiquitous calcium sensor calmodulin. We analyzed calmodulin function on the KCNQ2 channel in both HEK293 cells and neurons. ...
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نظر به اهمیت و تاثیر روزافزون عوامل روانی – اجتماعی در سلامت جسمی و تاثیر عوامل روان شناختی در بروز بیماریهای مختلف از جمله بیماریهای قلبی و عروقی این پژوهش با هدف کلی بررسی ارتباط تیپ شخصیتی d ، حمایت اجتماعی و خود دلسوزی در پیش بینی رفتارهای بهداشتی بیماران کرونر قلبی و تعیین تفاوت بین بیماران کرونر قلبی با و بدون جراحی و افراد سالم در این متغیرها و رفتارهای بهداشتی آنان، انجام گرفت. جامعه آ...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2019
ISSN: 1601-1848,1601-183X
DOI: 10.1111/gbb.12599