Heterologous prime-boost viral vector cancer vaccines have protective effects against a syngeneic mouse model of glioblastoma
نویسندگان
چکیده
Abstract Glioblastomas are immunologically “cold” tumors with intense immunosuppressive myeloid cell- and sparse cytotoxic T-cell infiltration. Therefore, viral vector vaccines may be a promising approach to boost the induction of glioblastoma-targeted T cells. It has been previously shown that heterologous prime-boost vaccination chimpanzee-derived adenovirus ChAdOx1 modified vaccinia Ankara (MVA) vectors can induce high magnitude CD8 +T cells specific for cancer-associated antigens have therapeutic effects against mouse models cancer. we aimed evaluate whether using MVA targeting model antigen P1A, equivalent human tumor-associated Melanoma Antigen GenE (MAGE)-type antigens, could protective P1A-transfected BGL-1 glioblastoma model. Mice were vaccinated ChAdOx1/MVA-P1A vaccines, then challenged subcutaneously P1A-expressing Prophylactic significantly prolonged survival syngeneic mice tumors. Furthermore, different schedules impacted antigen-specific +T-cell responses efficacy. Future studies will investigate intracranial BGl-1 Supported by grants from Ludwig Institute Cancer Research, University Oxford; NIH Intramural Program (ZIA BC011877), Oxford-Cambridge Scholars Program, Marshall Scholarship Program.
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.145.12