Heterologous prime-boost COVID-19 vaccination: initial reactogenicity data
نویسندگان
چکیده
منابع مشابه
Improved immunogenicity of mycobacterium tuberculosis Rv0577 by a heterologous prime-boost vaccination strategy in mice
Tuberculosis (TB) remains a major cause of global mortality and morbidity. However, the only available vaccine, Mycobacterium bovis bacillus Calmette-Guerin (BCG), is insufficiently effective against this disease. Therefore, the development of a potent vaccine against TB is urgently needed. Virulence-associated protein Rv0577 from Mycobacterium tuberculosis was demonstrated to induce the matura...
متن کاملHeterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials
Currently, there are more than 30 million people infected with HIV-1 and thousands more are infected each day. Vaccination is the single most effective mechanism for prevention of viral disease, and after more than 25 years of research, one vaccine has shown somewhat encouraging results in an advanced clinical efficacy trial. A modified intent-to-treat analysis of trial results showed that infe...
متن کاملHeterologous prime-boost vaccination with the LACK antigen protects against murine visceral leishmaniasis.
This study reports the efficacy of a heterologous prime-boost vaccination using DNA and vaccinia viruses (Western Reserve [WR] virus and modified [attenuated] vaccinia virus Ankara [MVA]) expressing the LACK antigen (Leishmania homologue of receptors for activated C kinase) and an intradermal murine infection model employing Leishmania infantum. At 1 month postinfection, vaccinated mice showed ...
متن کاملA Heterologous Prime/Boost Vaccination Strategy Enhances the Immunogenicity of Therapeutic Vaccines for Hepatitis C Virus
BACKGROUND We explored the concept of heterologous prime/boost vaccination using 2 therapeutic vaccines currently in clinical development aimed at treating chronically infected hepatitis C virus (HCV) patients: prime with a DNA-based vaccine expressing HCV genotype 1a NS3/4A proteins (ChronVac-C) and boost with a modified vaccinia virus Ankara vaccine expressing genotype 1b NS3/4/5B proteins (M...
متن کاملHeterologous Prime-Boost Vaccination Enhances TsPmy’s Protective Immunity against Trichinella spiralis Infection in a Murine Model
TsPmy is a paramyosin expressed by parasitic Trichinella spiralis and confers a protective immunity when its recombinant protein or DNA was used as an immunogen. To improve its immunogenicity and vaccine efficacy, we conducted a heterologous prime-boost strategy by orally delivering one dose of TsPmy DNA carried by attenuated Salmonella typhimurium (SL7207), followed by two doses of recombinant...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Lancet
سال: 2021
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(21)01115-6