Heterogeneity of human effector CD4+ T cells

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Heterogeneity of human effector CD4+ T cells

For many years the heterogeneity of CD4+ T-helper (Th) cells has been limited to Th1 and Th2 cells, which have been considered not only to be responsible for different types of protective responses, but also for the pathogenesis of many disorders. Th1 cells are indeed protective against intracellular microbes and they are thought to play a pathogenic role in organ-specific autoimmune and other ...

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Functional heterogeneity of human effector CD8+ T cells.

Effector CD8(+) T cells are believed to be terminally differentiated cells having cytotoxic activity and the ability to produce effector cytokines such as INF-γ and TNF-α. We investigated the difference between CXCR1(+) and CXCR1(-) subsets of human effector CD27(-)CD28(-)CD8(+) T cells. The subsets expressed cytolytic molecules similarly and exerted substantial cytolytic activity, whereas only...

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IMMUNOBIOLOGY Functional heterogeneity of human effector CD8 T cells

Effector CD8 T cells are believed to be terminally differentiated cells having cytotoxic activity and the ability to produce effector cytokines such as INFand TNF. We investigated the difference between CXCR1 and CXCR1 subsets of human effector CD27 CD28 CD8 T cells. The subsets expressed cytolytic molecules similarly and exerted substantial cytolytic activity, whereas only the CXCR1 subset had...

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CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis.

RATIONALE CD4 T cells are involved in the pathogenesis of atherosclerosis, but atherosclerosis-specific CD4 T cells have not been described. Moreover, the chemokine(s) that regulates T-cell trafficking to the atherosclerotic lesions is also unknown. OBJECTIVE In Apoe(-/-) mice with mature atherosclerotic lesions (5 months of high fat diet), we find that most aortic T cells express CCR5 and in...

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Dendritic cells (DC) initiate the differentiation of CD4+ helper T cells into effector cells including Th1 and Th17 responses that play an important role in inflammation and autoimmune disease pathogenesis. In mice, Th1 and Th17 responses are regulated by different conventional (c) DC subsets, with cDC1 being the main producers of IL-12p70 and inducers of Th1 responses, while cDC2 produce IL-23...

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ژورنال

عنوان ژورنال: Arthritis Research & Therapy

سال: 2009

ISSN: 1478-6354

DOI: 10.1186/ar2843