Heterogeneity among Lgr5-positive colon stem cells
نویسندگان
چکیده
منابع مشابه
Heterogeneity of the Level of Activity of Lgr5+ Intestinal Stem Cells
Intestinal stem cells (ISCs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. Lineage tracing experiments in mice have proven that ISCs can repopulate the entire intestinal crypt. It is noteworthy that in such experiments, only a subset of intestinal cr...
متن کاملheterogeneity of the level of activity of lgr5+ intestinal stem cells
intestinal stem cells (iscs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. lineage tracing experiments in mice have proven that iscs can repopulate the entire intestinal crypt. it is noteworthy that in such experiments, only a subset of intestinal cr...
متن کاملReg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.
Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5(+)) stem cells reside at crypt bottoms of the small and large intestine. Small intestinal Paneth cells supply Wnt3, EGF, and Notch signals to neighboring Lgr5(+) stem cells. Whereas the colon lacks Paneth cells, deep crypt secretory (DCS) cells are intermingled with Lgr5(+) stem cells at crypt bottoms. Here, we report re...
متن کاملLgr5-Positive Cells are Cancer-Stem-Cell-Like Cells in Gastric Cancer.
BACKGROUND/AIMS Effective treatment of gastric cancer (GC) requires better understanding of the molecular regulation of its carcinogenesis. Identification of cancer stem cells (CSCs) in GC appears to be a critical question. METHODS We analyzed Lgr5 expression in GC specimen. We used an adeno-associated virus (AAV) that carries diphtheria toxin fragment A (DTA) under the control of Lgr5 promot...
متن کاملHeterogeneity of the Level of Activity of Lgr5+ Intestinal Stem Cells
Intestinal stem cells (ISCs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal epithelial homeostasis and regeneration following injury or inflammation. Lineage tracing experiments in mice have proven that ISCs can repopulate the entire intestinal crypt. It is noteworthy that in such experiments, only a subset of intestinal cr...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2017
ISSN: 2372-3556
DOI: 10.1080/23723556.2017.1335271