Hereditary Human Complement C3 Deficiency Owing to Reduced Levels of C3 mRNA
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چکیده
منابع مشابه
C3 and C4 Complement Levels in Iron Deficiency Anemia
Background and Objectives: Complement proteins are some of the most important plasma proteins of the innate immune system. Impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. This study was conducted to show whether serum C3 and C4 complement change in adult nonpregnant female with iron deficient anemia or ...
متن کاملc3 and c4 complement levels in iron deficiency anemia
background and objectives: complement proteins are some of the most important plasma proteins of the innate immune system. impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. this study was conducted to show whether serum c3 and c4 complement change in adult nonpregnant female with iron deficient anemia or ...
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The complement system is an essential part of innate immunity acting as afirst-line defense against infection and provides an interface between innate and adaptive immunity (1,2). It consists of a network of soluble (fluid phase) and cell membrane proteins (solid phase). The key step in the complement cascade is the cleavage of C3 to C3a and C3b leading to the formation of a C3 convertase via t...
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The molecular mechanism of C3 deficiency in an Afrikaans patient with recurrent pyogenic infections was studied. Restriction enzyme analysis showed a gene deletion of 800 base pairs (bp) mapping to the alpha chain of C3. Amplification of genomic DNA, using the PCR, demonstrated that the deletion included exons 22 and 23 of the C3 gene. Truncated mRNA was shown in an Epstein-Barr virus-transform...
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From the implications of the complement system in a large number of diseases, an urgent need for therapeutics effecting reduced complement activity in vivo has emerged. In this study we report the design of a novel class of enzymes of human origin that obliterate functional complement by a noninhibitory, catalytic mechanism. Combining the framework of human C3 and the enzymatic mechanism of cob...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2001
ISSN: 0300-9475
DOI: 10.1046/j.1365-3083.2001.00934.x