Hereditary Fragility of Bone

Aging and fragility of bone.

Skeletal fragility and bone quality.

Bone Fragility in Hemodialysis Patients

Bone composition: relationship to bone fragility and antiosteoporotic drug effects.

The composition of a bone can be described in terms of the mineral phase, hydroxyapatite, the organic phase, which consists of collagen type I, noncollagenous proteins, other components and water. The relative proportions of these various components vary with age, site, gender, disease and treatment. Any drug therapy could change the composition of a bone. This review, however, will only addres...

Osteopontin deficiency increases bone fragility but preserves bone mass.

The ability of bone to resist catastrophic failure is critically dependent upon the material properties of bone matrix, a composite of hydroxyapatite, collagen type I, and noncollagenous proteins. These properties include elastic modulus, hardness, and fracture toughness. Like other aspects of bone quality, matrix material properties are biologically-defined and can be disrupted in skeletal dis...