Hereditary Conditions Associated with Elevated Cancer Risk in Childhood

Abstract Widespread use of the next-generation sequencing (NGS) technologies revealed that a significant percentage tumors in children develop as part monogenic hereditary diseases. Predisposition to development pediatric neoplasms is characteristic wide range conditions including tumor syndromes, primary immunodeficiencies, RASopathies, and phakomatoses. The mechanisms molecular pathogenesis are diverse include disturbances signaling cascades, defects DNA repair, chromatin remodeling, microRNA processing. Timely diagnosis tumor-associated syndromes important for proper choice cancer treatment, genetic counseling families, surveillance programs. review describes spectrum most common these