Hereditary Breast Cancer: Clinical, Pathological and Molecular Characteristics
نویسندگان
چکیده
منابع مشابه
Hereditary Breast Cancer: Clinical, Pathological and Molecular Characteristics
Pathogenic mutations in BRCA1 or BRCA2 are only detected in 25% of families with a strong history of breast cancer, though hereditary factors are expected to be involved in the remaining families with no recognized mutation. Molecular characterization is expected to provide new insight into the tumor biology to guide the search of new high-risk alleles and provide better classification of the g...
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Claudin-low breast cancer is a molecular type of breast cancer originally identified by gene expression profiling and reportedly associated with poor survival. Claudin-low tumors have been recognised to preferentially display a triple-negative phenotype, however only a minority of triple-negative breast cancers are claudin-low. We sought to identify an immunohistochemical profile for claudin-lo...
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background and purpose: breast cancer is the most common cause of cancer-specific mortality among women worldwide. this study aimed at investigating the epidemiological, clinical, and pathological characteristics of breast cancer among patients attending baghban clinic in sari. materials and methods: the patients’ records (2008-2014) were used and data including age, gender, marital status, men...
متن کاملThe molecular pathology of hereditary breast cancer.
Hereditary breast cancer arising in carriers of mutations in the BRCA1 and BRCA2 genes differs from sporadic breast cancer and from non-BRCA1/2 familial breast carcinomas. Most BRCA1 carcinomas have the basal-like phenotype and are high-grade, highly proliferating, estrogen receptor-negative and HER2-negative breast carcinomas, characterized by the expression of basal markers such as basal kera...
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Abstract Background: Many disease susceptibility genes are large and consist of many exons in which point mutations are scattered throughout. Scanning each exon individually represents a tedious task which can be time consuming and expensive. There has been increasing demand for rapid and accurate methods for full scanning of unknown point mutations in large multi-exon genes. Gene Assembling i...
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ژورنال
عنوان ژورنال: Breast Cancer: Basic and Clinical Research
سال: 2014
ISSN: 1178-2234,1178-2234
DOI: 10.4137/bcbcr.s18715