Hereditary and Familial Colon Cancer

Hereditary and familial colon cancer.

Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis conditions. Each is associated with a high risk of colon cancer. In addition to the syndromes, up to one-third of colon cancers exhibit increased familial risk, likely related to ...

Hereditary non-polyposis colon cancer.

This is an autosomal dominant highly penetrant cancer-susceptibility syndrome causedby germline mutations inone oftheDNAmismatch repair genes, MLH1, MSH2, MSH6, PMS2 and PMS 1. Affected individuals have apredispositionto developing early onset colorectal cancer and endometrial cancer, and less commonly ovarian, small intestine, stomach, biliary tract, pancreatic, brain and uroepithelial tract c...

Prevention of early-onset familial/hereditary colon cancer: new models and mechanistic biomarkers (review).

Human colon cancer is a multi-factorial, multi-step disease wherein genetic and dietary factors represent important regulators of initiation, promotion and progression. While the etiology of sporadic colon cancer remains largely unidentified, familial adenomatous polyposis (FAP) and hereditary non-polyposis colon cancer (HNPCC) represent predisposing genetic syndromes for early-onset familial/h...

Familial cancer of the colon and rectum.

A familial relationship between intestinal polyposis and the predisposition of polyposis to colonic cancer has been accepted since the publication in 1952/1953 of Dukes's paper. He collected information on every patient presenting at St Mark's Hospital with polyposis coli and investigated the family background in each case. He was able to study 41 families, trace 156 cases of polyposis, and 114...

Molecular Pathology of Hereditary Colon Cancer