Her-2/neu gene amplification compared with HER-2/neu protein overexpression on ultrasound guided core-needle biopsy specimens of breast carcinoma
نویسندگان
چکیده
منابع مشابه
Fluorescence in situ hybridization for HER-2/neu amplification of breast carcinoma in archival fine needle aspiration biopsy specimens.
OBJECTIVE To assess the usefulness of fluorescence in situ hybridization (FISH) for HER-2/neu amplification of breast carcinoma in archival fine needle aspiration biopsy (FNAB) specimens. STUDY DESIGN All FISH performed on formalin-fixed, paraffin-embedded surgical specimens during January 2003-August 2003 at the University of California Irvine Medical Center were selected. Prior FNABs were r...
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Pleomorphic variant of lobular carcinoma is a recently described variant of invasive lobular carcinoma. It is reported to be positive for estrogen receptors and progesterone receptors and over express Her2/neu in most cases. We present here a case of invasive variant of pleomorphic lobular carcinoma with coexisting classic and pleomorphic variants of lobular carcinoma in situ along with focal d...
متن کاملUltrasound-guided core-needle biopsy of breast lesions
OBJECTIVE: To review the role of ultrasound-guided core-needle biopsy (CNB) in the management of breast lesions. METHODS: Review of the most relevant literature on this topic. RESULTS: This technique shows a high sensitivity value of about 97.5% and it offers many advantages over other imaging techniques to guide a biopsy: non-ionising radiation, low cost, full control of the needle in real t...
متن کاملReview: significance of, and optimal screening for, HER-2 gene amplification and protein overexpression in breast carcinoma.
Breast carcinoma is a common disease, with an estimated 183,000 new cases expected in the USA during 2000. Whereas early stage patients have high likelihood of cure, only 20-40% of patients with metastatic breast carcinoma respond to presently available chemotherapy. A need exists to identify the underlying biological subsets of morphologically similar carcinomas in order to develop customized ...
متن کاملAnatomic Pathology / PAPILLOMAS AND ATYPICAL PAPILLOMAS IN BREAST CORE NEEDLE BIOPSY SPECIMENS Papillomas and Atypical Papillomas in Breast Core Needle Biopsy Specimens Risk of Carcinoma in Subsequent Excision
We sought to define the risk associated with papillomas and atypical papillomas in breast core needle biopsy specimens from a series of approximately 8,500 biopsies performed during 8 years. From a total of 62 papillary lesions (including papillomas and atypical papillomas), 40 (65%) had histologic followup. Overall, 15 (38%) of 40 patients had ductal carcinoma in situ (12 cases) or invasive ca...
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ژورنال
عنوان ژورنال: Pathology & Oncology Research
سال: 2001
ISSN: 1219-4956
DOI: 10.1007/bf03032384