منابع مشابه
Properties of Phenylalanine Hydroxylase of Cultured Hepatoma
The kinetic and immunologic properties of phenylalanine hydroxylase of adult rat liver were compared to the properties of the similar enzyme present in cultured H4-II-E-C3 hepatoma cells. The enzymes from the two sources could not be distinguished by the K, values for either phenylalanine or 6,7-dimethyltetrahydropterin. Analysis by double immunodiffusion showed that phenylalanine hydroxylase f...
متن کاملProperties of phenylalanine hydroxylase of cultured hepatoma cells.
The kinetic and immunologic properties of phenylalanine hydroxylase of adult rat liver were compared to the properties of the similar enzyme present in cultured H4-II-E-C3 hepatoma cells. The enzymes from the two sources could not be distinguished by the Km values for either phenylalanine or 6,7-dimethyltetrahydropterin. Analysis by double immunodiffusion showed that phenylalanine hydroxylase f...
متن کاملInteraction of glucocorticoid hormones and cyclic nucleotides in induction of tyrosine aminotransferase in cultured hepatoma cells.
Reproducible induction of the enzyme tyrosine aminotransferase by dibutyryl cAMP (Bt2cAMP) in a line of HTC hepatoma cells in suspension culture requires that the cells be preinduced with dexamethasone, a synthetic glucocorticoid which itself induces tyrosine aminotransferase. Concentrations of dexamethasone that do not induce tyrosine aminotransferase fail to support Bt2cAMP induction, removal...
متن کاملCytotoxic effects of two novel 8-substituted cyclkic nucleotide derivaties in cultured rat hepatoma cells.
The cytotoxic effects of two structurally related cyclic nucleotide analogs have been investigated in a cultured rat hepatoma cell line (H35). Both analogs, 8-H2NcAMP and 8-OH(CH2)2HNcAMP, were lethal to growing H35 cells, exhibiting LC5o’s of 5-10 and approximately 50-80 ,.t i, respectively. The potency of both analogs was significantly reduced by the concomitant addition of the phosphodiester...
متن کاملProduction of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells.
Infections with hepatitis C virus (HCV) are marked by frequent viral persistence, chronic liver disease, and extraordinary viral genetic diversity. Although much has been learned about HCV since its discovery, progress has been slowed by a lack of permissive cell culture systems supporting its replication. Productive infections have been achieved recently with genotype 2a virus, but cirrhosis a...
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ژورنال
عنوان ژورنال: NIPPON SUISAN GAKKAISHI
سال: 1971
ISSN: 1349-998X,0021-5392
DOI: 10.2331/suisan.37.676