Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.

Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates fatty acid transport and metabolism. Previous studies revealed that PPARα can affect bile acid metabolism; however, the mechanism by which PPARα regulates bile acid homeostasis is not understood. In this study, an ultraperformance liquid chromatography coupled with electrospray ionization qua dru pole time...

Peroxisome Proliferator-Activated Receptor

Peroxisome proliferator - activated receptor

The peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. The discovery of PPARγ as a target of multimodal insulin sensitizers has attracted remarkable scientific interest and had a great impact on the pharmaceutical industry. Thi...

Peroxisome Proliferator-Activated Receptor

Role of Peroxisome Proliferator-Activated Receptor α in Diabetic Nephropathy

With a developing worldwide epidemic of diabetes mellitus, the renal complications associated with diabetes have become a serious health concern. Primary therapy for treating diabetic nephropathy is a multifactorial process. Peroxisome proliferator-activated receptor alpha (PPARα) agonists have been used primarily in clinical practice for the treatment of dyslipidemia and insulin resistance. Gi...