Hepatocyte growth factor plays a dual role in regulating skeletal muscle satellite cell proliferation and differentiation
نویسندگان
چکیده
منابع مشابه
Hepatocyte growth factor affects satellite cell activation and differentiation in regenerating skeletal muscle.
Hepatocyte growth factor (HGF) is the only known growth factor that activates quiescent satellite cells in skeletal muscle. We hypothesized that local delivery of HGF may enhance regeneration after trauma by increasing the number of myoblasts available for restoring normal tissue architecture. Injection of HGF into muscle at the time of injury increases myoblast number but does not enhance tiss...
متن کاملSatellite cell activation in stretched skeletal muscle and the role of nitric oxide and hepatocyte growth factor.
In the present study, we examined the roles of hepatocyte growth factor (HGF) and nitric oxide (NO) in the activation of satellite cells in passively stretched rat skeletal muscle. A hindlimb suspension model was developed in which the vastus, adductor, and gracilis muscles were subjected to stretch for 1 h. Satellite cells were activated by stretch determined on the basis of 5-bromo-2'-deoxyur...
متن کاملSatellite cell proliferation and differentiation during postnatal growth of porcine skeletal muscle.
Age-related changes in satellite cell proliferation and differentiation during rapid growth of porcine skeletal muscle were examined. Satellite cells were isolated from hindlimb muscles of pigs at 1, 7, 14, and 21 wk of age (4 animals/age group). Satellite cells were separated from cellular debris by using Percoll gradient centrifugation and were adsorbed to glass coverslips for fluorescent imm...
متن کاملSatellite Cell Proliferation in Adult Skeletal Muscle
England et al. (1990), Very mild muscular dystrophy associated with the deletion of 46% of dystrophin., Nature, 343:180-182. Gilboa et al. (1986), Transfer and Expression of Cloned Genes Using Retroviral Vectors., Biotechniques, 4(6):5O4-5 12. Allbrook, D. (1981), Skeletal Muscle Regeneration, Muscle and Nerve, 4:234-245. Ishiura et al. (1986), Biochemical Aspects of Bupivacaine-Induced Acute M...
متن کاملHepatocyte Growth Factor from Mechanically Stretched Skeletal Muscle Satellite Cells and the Role of pH and Nitric Oxide
Application of mechanical stretch to cultured adult rat muscle satellite cells results in release of hepatocyte growth factor (HGF) and accelerated entry into the cell cycle. Stretch-activation of cultured rat muscle satellite cells was observed only when medium pH was between 7.1 and 7.5, even though activation of satellite cells was accelerated by exogenous HGF over a pH range from 6.9 to 7.8...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 1998
ISSN: 0167-4889
DOI: 10.1016/s0167-4889(97)00124-9