HEPATIC OSTEODYSTROPHY IN AUTOIMMUNE LIVER DISEASES

Osteodystrophy in chronic liver diseases.

Osteoporosis and osteomalacia are, to date, among the most common metabolic diseases in the world. Lately, an association between metabolic bone diseases and chronic liver disease has been increasingly reported, inducing many authors to create a new nosographic entity known as 'hepatic osteodystrophy.' The importance of such a condition is further increased by the morbidity of these two disease...

Hepatic osteodystrophy and liver cirrhosis.

AIM To investigate the correlation between hepatic osteodystrophy and osteoporosis in patients with liver cirrhosis. METHODS Bone mineral density of the patients (n = 55) and that of the control group (n = 30) were measured by dual-energy X-ray absorptiometry. All the women in the study were premenopausal. Deoxypyridinoline, pyridinoline and urinary Ca(2+) were measured as bone destruction ma...

Hepatic osteodystrophy: vitamin D metabolism in patients with liver disease.

Hepatic manifestations of autoimmune rheumatic diseases.

Hepatic manifestations in autoimmune disease include chronic active hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and nodular regenerative hyperplasia. These diseases are rare and may occur concomitantly or serially. Clinicians must be aware of the possibility of liver disease so that it can be treated as soon as possible.

Unmet clinical need in autoimmune liver diseases.

Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. Howev...