Hemolysis Interferes with the Detection of Anti–Tissue Transglutaminase Antibodies in Celiac Disease
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چکیده
منابع مشابه
Simultaneous Detection of IgA/IgG AntiTissue Transglutaminase/Deamidated Gliadin Peptides in Serodiagnosis of Celiac Disease
Background: Celiac disease is a common autoimmune disorder that is diagnosed based on clinical case identification, serological screening, and duodenal histology. However, the existence of mild clinical forms, such as seronegative cases with patchy atrophy and potential celiac disease, can make it difficult to determine a definitive diagnosis. The seronegative patients with celiac disease can i...
متن کاملAntitissue Transglutaminase IgA for Celiac Disease Testing.
A 23-year-old woman presented for assessment of positive celiac disease serologic testing. The testingwasperformedat thepatient’s requestbecauseher 15-year-oldbrotherwas diagnosed with celiac disease. Based on her test results, the patient was advised to commenceagluten-freediet.However, shebelieved that a small intestinal biopsywouldbeappropriate to confirm her diagnosis and sought another opi...
متن کاملsimultaneous detection of iga/igg antitissue transglutaminase/deamidated gliadin peptides in serodiagnosis of celiac disease
background: celiac disease is a common autoimmune disorder that is diagnosed based on clinical case identification, serological screening, and duodenal histology. however, the existence of mild clinical forms, such as seronegative cases with patchy atrophy and potential celiac disease, can make it difficult to determine a definitive diagnosis. the seronegative patients with celiac disease can i...
متن کاملHemolysis Interferes with the Detection of Anti–Tissue Transglutaminase Antibodies in Celiac Disease To the Editor: Detection of anti–tissue transglu- taminase (tTG) antibodies by the use of human recombinant or erythrocyte tTG-IgA– based ELISA
1. Biller BM, Grossman AB, Stewart PM, Melmed S, Bertagna X, Bertherat J, et al. Treatment of adrenocorticotropin-dependent Cushing’s syndrome: a consensus statement. J Clin Endocrinol Metab 2008;93:2454–62. 2. Yanovski JA, Cutler GB Jr, Chrousos GP, Nieman LK. Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration: a new test to distinguish Cushing’s syndro...
متن کاملImmunohistochemical Expression of Antitissue Transglutaminase 2 in Tissue Injuries: An Interpretation Beyond Celiac Disease.
Tissue transglutaminase 2 enzyme plays a diverse role in intracellular and extracellular functioning. Aberrant expression of anti-TG2 antibody has recently been proposed for extraintestinal identification of celiac disease (CeD), but its utility is questionable. To examine whether anti-TG2 immunohistochemical (IHC) staining can be of diagnostic value in identifying extraintestinal involvement i...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2010
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2009.141242