Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response
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چکیده
منابع مشابه
Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response.
BACKGROUND Hemojuvelin is a glycosylphosphatidylinositol-anchored protein, expressed in liver, skeletal muscle and heart. As a co-receptor of bone morphogenetic protein, membrane hemojuvelin positively modulates the iron regulator hepcidin. Mutations of the gene encoding for hemojuvelin cause juvenile hemochromatosis, characterized by hepcidin deficiency and severe iron overload. We have previo...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2008
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.12508