Hemoglobin D Iran α2A β222-Glu→Gln in Association With Thalassemia
نویسندگان
چکیده
منابع مشابه
Hemoglobin D Iran a in Association With Thalassemia
A 25-yr-old Indian (Asiatic) woman investigated for a life-long anemia was found to have a hitherto undescribed structural hemoglobin variant gIn which was found independently and designated Hb D Iran by Rahbar in members of a family from Iran. In the present case, Hb D Iran was found in association with high A2 thalassemia. The replacement of glutamic acid by glutamine at fi 22 (helical residu...
متن کاملHemoglobin D Los Angeles in two Caucasian families: hemoglobin SD disease and hemoglobin D thalassemia.
11 EMOGLOBIN D LOS ANGELES, a2,82121g1m,l (Or D Punjab) is one of I I the more common hemoglobin variants, since it occurs in about 3 per cent of the Sikhs of the Punjab2 and sporadically in other ethnic groups, particularly those that have had considerable contact with India. In electrophoresis and chromatography, this variant is indistinguishable from hemoglobin S; however, it lacks the insol...
متن کاملHemoglobin D Los Angeles in Two Caucasian Families: Hemoglobin SD Disease and Hemoglobin D Thalassemia
11 EMOGLOBIN D LOS ANGELES, a2,82121g1m,l (Or D Punjab) is one of I I the more common hemoglobin variants, since it occurs in about 3 per cent of the Sikhs of the Punjab2 and sporadically in other ethnic groups, particularly those that have had considerable contact with India. In electrophoresis and chromatography, this variant is indistinguishable from hemoglobin S; however, it lacks the insol...
متن کاملHomozygous hemoglobin D with alpha thalassemia: case report
Hb D is a clinically silent condition, but co-inheritance of Hb D with sickle cell or thalassemia produces clinically significant conditions like sickle cell anemia or thalassemia intermedia and chronic hemolytic anemia of moderate severity. Here we present a case of homozygous Hb D with alpha 3.7kb deletion and phenotypic effect on patients. Diagnosis of Hb D patient was performed by high perf...
متن کاملCombined α-thalassemia and Hemoglobin J-Iran (β77 His → Asp). A Family Study in southern Iran
We report a 23-year-old man and three members of his family with Hb J-Iran confirmed by electrophoresis, chain separation by high performance liquid chromatography and sequencing. Alpha thalassemia was also confirmed in two family members. The substitution at β77 led to a higher negative charge of the βJ-Iran subunit, which enhanced its electrostatic attraction for the normal positively-charged...
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ژورنال
عنوان ژورنال: Blood
سال: 1973
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v42.3.455.455