Hemochromatosis: 1980 update

Hemochromatosis Update.

Hereditary hemochromatosis: update for 2003.

The term ‘hemochromatosis’ was first used by von Recklinghausen, a German pathologist in the late 1800s [1]; he determined that the pigmentation seen in patients with advanced hemochromatosis was due to iron. In 1935, Joseph Sheldon, a British geriatrician, published a monograph describing over 300 patients with hemochromatosis [2]. He concluded that the disorder was an inherited defect with al...

Hereditary hemochromatosis : update for 2003 Stephen

The term ‘hemochromatosis’ was first used by von Recklinghausen, a German pathologist in the late 1800s [1]; he determined that the pigmentation seen in patients with advanced hemochromatosis was due to iron. In 1935, Joseph Sheldon, a British geriatrician, published a monograph describing over 300 patients with hemochromatosis [2]. He concluded that the disorder was an inherited defect with al...

Iron is hot: an update on the pathophysiology of hemochromatosis.

GENETIC IRON OVERLOAD disorders are prevalent yet poorly understood. Over the past 3 years, the discoveries of the hereditary hemochromatosis gene and an intestinal iron transporter have significantly advanced our understanding of iron metabolism. Furthermore, they have suggested novel links between molecules involved in immune defense and iron homeostasis. These findings lay the foundation for...

Secondary hemochromatosis. I. Transfusion (exogenous) hemochromatosis.

(" bronszed diabetes ") is a condition of unknown etiology in which the body iron stores are vastly inscreased ansd in which there is portal cirrhosis of the liver. Diabetes, pigmenstation of the skins, and pan-creatic fibrosis are frequently, though not invariably, present. Numerous blood transsfusionss ins certain patienits have resulted ins the productions of a condition clinically somewhat ...