Heme oxygenase 1: a novel oncogene in multiple gynecological cancers
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چکیده
منابع مشابه
Heme oxygenase-1: a novel drug target for atherosclerotic diseases?
Schmid and coworkers1 were the first to report on the presence of heme oxygenase (HO) in liver microsomes capable of degrading heme to bilirubin, and this activity was subsequently dissociated from cytochrome P-450.2,3 HO catalyzes the first and rate-limiting step in the oxidative degradation of heme (Fe-protoporphyrin-IX) to carbon monoxide (CO), ferrous iron (Fe ), and biliverdin-IX (Figure 1...
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Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in the catabolism of heme, followed by production of biliverdin, free iron and carbon monoxide (CO). HO-1 is a stress-responsive protein induced by various oxidative agents. Recent studies demonstrate that the expression of HO-1 in response to different inflammatory mediators may contribute to the resolution of inflammation and has protective ...
متن کاملHeme Oxygenase-1 as a Novel Metabolic Player
hydrogen donor: oxygen oxidoreductase (í µí»¼-methene hydroxylating, decycliz-ing)) catalyzes the rate limiting the step in the oxidative catabolism of heme to generate biliverdin-IXí µí»¼, which is subsequently converted to bilirubin-IXí µí»¼ by cytosolic NAD(P)H-dependent biliverdin reductase [1]. This reaction, which requires molecular oxygen as well as electrons from NADPH-dependent cytochr...
متن کاملThe Expression of Heme Oxygenase-1 in Human-Derived Cancer Cell Lines
Background: Heme oxygenase-1 (HO-1) is a cytoprotective and antiapoptotic enzyme, which has been involved in maintaining cellular homeostasis, and plays an important protective role by modulating oxidative injury. Up-regulation of (HO-1) has contributed to tumorogenicity of some cancers. In this study we investigated the expression pattern of the HO-1, in five different human-derived cancer cel...
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Cardiovascular risk factors contribute to enhanced oxidative stress which leads to endothelial dysfunction. These events trigger platelet activation and their interaction with leukocytes and endothelial cells, thus contributing to the induction of chronic inflammatory processes at the vascular wall and to the development of atherosclerotic lesions and atherothrombosis. In this scenario, endogen...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2021
ISSN: 1449-2288
DOI: 10.7150/ijbs.61073