Hematopoietic Stem Cells Self-Renew Symmetrically or Gradually Proceed to Differentiation
نویسندگان
چکیده
منابع مشابه
Adult hematopoietic stem cells lacking Hif-1α self-renew normally.
The hematopoietic stem cell (HSC) pool is maintained under hypoxic conditions within the bone marrow microenvironment. Cellular responses to hypoxia are largely mediated by the hypoxia-inducible factors, Hif-1 and Hif-2. The oxygen-regulated α subunits of Hif-1 and Hif-2 (namely, Hif-1α and Hif-2α) form dimers with their stably expressed β subunits and control the transcription of downstream hy...
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Purpose: Differentiation of Mouse embryonicstem cells into Hematopoietic cells. Materials and Methods: In this study, we used EB formation system for Hematopoietic differentiation of mouse embryonic stem cell (Royan B1) in suspension culture. EBs cultured in medium with Hematopoietic inducer cytokines (SCF, TPO, GMCSF, IL3, Flt3 and EPO) .presence of hematopoietic differentiated cell assessed ...
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1 Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA 2 Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA 3 Universal Biology Institute, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan 4 Departments of Dermatology & Cell Biology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA # Equal contrib...
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1Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA 2Department of Pathology and Laboratory Medicine, Stowers Institute for Medical Research, University of Kansas School of Medicine, Kansas City, MO 64110, USA 3Terry Fox Laboratory, British Columbia Cancer Agency and Department of Medicine, Unive...
متن کاملSelf-renewal and differentiation of hematopoietic stem cells.
Hematopoietic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into all blood lineage cells. The fate decisions of HSCs (self-renewal versus differentiation) are made through the process of cell division and are often compared to "birth" and "death". Stem cells give rise to undifferentiated stem cells (birth) or differentiate into progenitor cells (death). Th...
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ژورنال
عنوان ژورنال: SSRN Electronic Journal
سال: 2021
ISSN: 1556-5068
DOI: 10.2139/ssrn.3787896