Hematopoietic stem cells: generation and self-renewal
نویسندگان
چکیده
منابع مشابه
Predicting clonal self-renewal and extinction of hematopoietic stem cells.
A single hematopoietic stem cell (HSC) can generate a clone, consisting of daughter HSCs and differentiated progeny, which can sustain the hematopoietic system of multiple hosts for a long time. At the same time, this massive expansion potential must be restrained to prevent abnormal, leukemic proliferation. We used an interdisciplinary approach, combining transplantation assays with mathematic...
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1Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA 2Department of Pathology and Laboratory Medicine, Stowers Institute for Medical Research, University of Kansas School of Medicine, Kansas City, MO 64110, USA 3Terry Fox Laboratory, British Columbia Cancer Agency and Department of Medicine, Unive...
متن کاملSelf-renewal and differentiation of hematopoietic stem cells.
Hematopoietic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into all blood lineage cells. The fate decisions of HSCs (self-renewal versus differentiation) are made through the process of cell division and are often compared to "birth" and "death". Stem cells give rise to undifferentiated stem cells (birth) or differentiate into progenitor cells (death). Th...
متن کاملHematopoietic Stem Cells Count and Remember Self-Renewal Divisions
The ability of cells to count and remember their divisions could underlie many alterations that occur during development, aging, and disease. We tracked the cumulative divisional history of slow-cycling hematopoietic stem cells (HSCs) throughout adult life. This revealed a fraction of rarely dividing HSCs that contained all the long-term HSC (LT-HSC) activity within the aging HSC compartment. D...
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The Smad-signaling pathway downstream of the transforming growth factor-beta superfamily of ligands is an evolutionarily conserved signaling circuitry with critical functions in a wide variety of biologic processes. To investigate the role of this pathway in the regulation of hematopoietic stem cells (HSCs), we have blocked Smad signaling by retroviral gene transfer of the inhibitory Smad7 to m...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2007
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4402225