Hematopoietic stem cell niche maintenance during homeostasis and regeneration
نویسندگان
چکیده
منابع مشابه
The hematopoietic stem cell niche in homeostasis and disease.
The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we review recent studies that highlight the heterogeneity of the stromal cells t...
متن کاملPerspectives The hematopoietic stem cell niche in homeostasis and disease
The hematopoietic system requires constant replenishment of its end products, a large and heterogeneous array of terminally differentiated cells and corpuscles, which are essential for oxygenation, clotting, and immunity. Because this daily requirement continues throughout the life of an individual, hematopoietic stem cells (HSCs), the cells at the apex of this well-orchestrated hierarchy, requ...
متن کاملThe hematopoietic stem cell niche.
Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells found within the highly specialized microenvironment termed the hematopoietic stem cell niche. Understanding and exploiting the HSC niche is a goal of basic scientists and cl...
متن کاملStem cells and their niche in homeostasis/regeneration and disease
Yukiko M. Yamashitaa and Tudorita Tumbarb aLife Sciences Institute, University of Michigan, Ann Arbor, Ann Arbor, MI 48109-2216; bDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 Gage Crump (University of Southern California) presented evidence for a transfating of chondrocytes to the osteoblasts that rebuild bone during jawbone regeneration in zebrafish. Such ...
متن کاملDivisional History and Hematopoietic Stem Cell Function during Homeostasis
We investigated the homeostatic behavior of hematopoietic stem and progenitor cells (HSPCs) temporally defined according to their divisional histories using an HSPC-specific GFP label-retaining system. We show that homeostatic hematopoietic stem cells (HSCs) lose repopulating potential after limited cell divisions. Once HSCs exit dormancy and accrue divisions, they also progressively lose the a...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2014
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.3647