Hematopoiesis and hematopoietic organs in arthropods
نویسندگان
چکیده
منابع مشابه
Hematopoietic stem cells and hematopoiesis.
BACKGROUND The highly orchestrated process of blood cell development and homeostasis is termed "hematopoiesis." Understanding the biology of hematopoietic stem cells as well as hematopoiesis is important to developing improved treatments for hematologic malignancies, congenital disorders, chemotherapy-related cytopenias, and blood and marrow transplants. METHODS The author reviews the current...
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A stem-cell niche can be defined as a spatial structure in which stem cells are housed and maintained by allowing self-renewal in the absence of differentiation. The concept of the stemcell niche was initially proposed in invertebrates where they were first characterized; the control of germ line stem cell maintenance and differentiation was observed in ovarian and testicular D. melanogaster ni...
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The establishment of the HSC pool in vertebrates depends not only on the formation and the propagation of these stem cells but also on their proper trafficking among the defined hematopoietic organs. However, the physiologic mechanisms that regulate HSC mobilization remain elusive. Through analysis of the zebrafish cmyb mutant cmybhkz3, we show that the suppression of cMyb function abrogates la...
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Hematopoietic development and vascular development are closely related physiological processes during vertebrate embryogenesis. Recently, endothelial-to-hematopoietic transition (EHT) was demonstrated to be critical for hematopoietic stem and progenitor cell induction, but its underlying regulatory mechanisms remain poorly understood. Here we show that thrombin receptor (F2r), a protease-activa...
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ژورنال
عنوان ژورنال: Development Genes and Evolution
سال: 2013
ISSN: 0949-944X,1432-041X
DOI: 10.1007/s00427-012-0428-2